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|Society & You - Health|
|Monday, 25 June 2012 17:48|
There are often false positives and negatives in screening for Down syndrome and Edwards syndrome . New research at Lucile Packard Children's Hospital at Stanford University, promising. In Demedicina.com tell you more of this revolutionary method.
Detection of Down syndrome and Edwards syndrome
Looking for other methods of detection of these syndromes
researchers used digital analysis of selected regions. (DANSR). This analysis examines the cell-free fetal cells DNA. The parts of DNA that circulate in the bloodstream of pregnant women.
A difference between this method and existing ones is that it focuses on examining only the chromosomes to be examined, so the process is faster and cheaper than other methods.
The technique is called Fetal-fraction of Trisonomy Optimized Risk Evaluation (FORTE)
What is this new technique?
The technique analyzes the percentages FORTE fetal DNA in the sample and the risks associated with age in order to determine if risk of these trisomies in the baby. This technique was tested on a sample of 4,002 women with a mean age of 34.3 years, from different countries and ethnicities.
Before having any evidence to determine whether there was risk of trisomy. They took blood samples from patients. The results were compared with those offered by conventional detection tests, CVS and amniocentesis.
We found 81 cases were diagnosed as having high risk of trisomy 21 or Down syndrome . FORTE The method identified 100% of these cases and only one false positive (compared with 2.88 in the rate of false positives that occur with the current tests).
This method gives FORTE a rate of only 0.03% false positives. Of the 38 cases at risk for T18 or Edwards syndrome, 37 were successfully identified and there were 2 false positives. This implies a 97.4% rate of success with a false positive rate of 0.07%.
Mary E. Norton, MD, director of perinatal research at Lucile Packard Children's Hospital at Stanford University, said:
The improvement achieved by the method DANSR provides a more accessible for analysis cfDNA with high performance and potential for use in the clinic. The cell-free DNA provide highly accurate results in a single analysis. It is potentially suitable as a replacement for current screening techniques.
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Sources | es.wikipedia.org, www.medicalnewstoday.com
Photos | agroecocartaya.blogspot.com/locosxla100cia.blogspot.com /